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Healthcare Professionals

The CLINUVEL
Group

We are a global biopharmaceutical company focused on developing and delivering treatments for patients with a range of severe genetic and skin disorders.

About Clinuvel

First US Patients to be treated with SCENESSE®.
Insurance companies initiate reimbursement of SCENESSE® (afamelanotide) for patients diagnosed with erythropoietic protoporphyria (EPP).

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Photomedicine

Pioneering the concept of
medicinal photoprotection

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Pharmaceuticals

Pioneers and leaders in understanding
the interaction of light and human biology.

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Photocare

We strive to expand our reservoir of knowledge
and expertise in the field of photocare.

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Social & Media

Join us on any of our social channels to keep
up to date on the latest developments.

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Clinical trials over
several indicators
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patients have been
treated with
SCENESSE®

Pharmaceuticals

SCENESSE®

CLINUVEL’s proprietary first-in-class photoprotective drug. SCENESSE® acts by increasing the levels of melanin in the skin; and shields against UV radiation (UVR) and sunlight. 

Erythropoietic Protoporphyria (EPP)

EPP is a rare metabolic disorder that causes severe anaphylactoid reactions to light (phototoxicity). Patients incur physical burns and ulcers, and are in a state of crisis following light exposure, summarised as phototoxicity.

Alpha-Melanocyte Stimulating Hormone (α-MSH)

A naturally occurring peptide hormone which is released by skin cells in response to the stimulation by ultraviolet radiation (UVR).

Photomedicine

Light and the
Environment

The wavelengths of light comprising the electromagnetic spectrum are fundamental to all life on Earth. Human eyes are only able to see a very small portion of the electromagnetic spectrum – visible light – which has wavelengths between approximately 400-700nm, but there are key roles played by light of different wavelengths.

The Spectrum of Photodermatoses

Different photodermatoses react with light (or electromagnetic energy)
at different wavelengths. Explore them below.

spectrum-v2
Xeroderma
Pigmentosum (XP)

250-300nm
Peak intensity for erythema at 293nm.
Click to read more about XP

 

Xeroderma
Pigmentosum (XP)

300-500nm
Click to read more about SU

 

Hydroa Vacciniforme (HV)

320-400nm
Triggered by Ultraviolet A (UVA) radiation
Click to read more about HV

 

Porphyria Cutanea
Tarda (PCT)

400nm
Excess porphyrins in the skin interact
with light forming reactive oxygen species.
Click to read more about PCT

 

Erythropoietic
Protoporphyria (EPP)

408nm
Additional peaks at 525nm, 550nm and 650nm.
Click to read more about EPP

 

Erythropoietic
Protoporphyria (EPP)

All sunlight
Specific wavelength depends
on the sensitivity of the individual.
Click to read more about PLE

 

Congenital Erythropoietic
Porphyria (CEP)

UV and Visible light
Diagnosis is based on uroporphyrin
I and coporphyrin I present in blood plasma
spectrofluorimetry seen at 615-620nm.
Click to read more about CEP

 

Variegate Porphyria (VP)

Diagnosed by the presence of a specific
plasma fluorometric emission at 626nm.
Click to read more about VP

 

Photomedicine

Electromagnetic
Spectrum

Energy travels and appears in many different forms.
The light energy that allows us to see is a form of electromagnetic radiation, however, this is only a fraction
of all electromagnetic radiation that exists. While the different types of radiation along the electromagnetic spectrum may seem unrelated, they all share similar properties.

Contacts

Questions?
Get in touch.

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