We are a global biopharmaceutical company focused on developing and delivering treatments for patients with a range of severe genetic and skin disorders.
First US Patients to be treated with SCENESSE®.
Insurance companies initiate reimbursement of SCENESSE® (afamelanotide) for patients diagnosed with erythropoietic protoporphyria (EPP).
Clinical trials over
patients have been
CLINUVEL’s proprietary first-in-class photoprotective drug. SCENESSE® acts by increasing the levels of melanin in the skin; and shields against UV radiation (UVR) and sunlight.
Erythropoietic Protoporphyria (EPP)
EPP is a rare metabolic disorder that causes severe anaphylactoid reactions to light (phototoxicity). Patients incur physical burns and ulcers, and are in a state of crisis following light exposure, summarised as phototoxicity.
Alpha-Melanocyte Stimulating Hormone (α-MSH)
A naturally occurring peptide hormone which is released by skin cells in response to the stimulation by ultraviolet radiation (UVR).
Light and the
The wavelengths of light comprising the electromagnetic spectrum are fundamental to all life on Earth. Human eyes are only able to see a very small portion of the electromagnetic spectrum – visible light – which has wavelengths between approximately 400-700nm, but there are key roles played by light of different wavelengths.
The Spectrum of Photodermatoses
Different photodermatoses react with light (or electromagnetic energy)
at different wavelengths. Explore them below.
Energy travels and appears in many different forms.
The light energy that allows us to see is a form of electromagnetic radiation, however, this is only a fraction
of all electromagnetic radiation that exists. While the different types of radiation along the electromagnetic spectrum may seem unrelated, they all share similar properties.